I-API Donepezil HCl CAS 120011-70-3 Isithombe Esifakiwe Sesifo Se-Alzheimer

I-API Donepezil HCl CAS 120011-70-3 Yesifo i-Alzheimer's

Incazelo emfushane:

I-Donepezil Hydrochloride usawoti we-hydrochloride wokuphuma kwe-piperidine onomsebenzi othuthukisa i-neurocognitive.I-Donepezil ivimbela ngokubuyisela emuva i-acetylcholinesterase, ngaleyo ndlela ivimbele i-hydrolysis ye-neurotransmitter acetylcholine futhi, ngenxa yalokho, ikhulise umsebenzi wayo.

Othintana naye: Erica Zheng

Email: erica@zhuoerchem.com

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Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Incazelo

I-Donepezil isetshenziselwa ukwelapha ukudideka okuhlobene nesifo i-Alzheimer's.

Ukucaciswa:

Igama Lomkhiqizo	I-Donepezil Hydrochloride
Igama Lekhemikhali	1h-inden-1-one,2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)me
Elinye Igama	I-Donepezil hcl;Donezepilhydrochloride;DonepezilHydrochloride(200mg);2-(1-Benzylpiperidin-4-yl)Methyl) -5,6-diMethoxy-2,3-dihydro-1H-inden-1-onehydrochloride;2,3-Dihydrochloride;2,3-Dihydrochloride; -5,6-diMetChemicalbookhoxy-2-[[1-(phenylMethyl)-4-piperidinyl]Methyl]-;2-(1-Benzyl-4-piperidylmethyl) -5,6-dimethoxy-1-indanoneHydrochloride;Donepezil(Aricept );I-DonepezilHydrochlorideForMⅠ
Inombolo ye-CAS	120011-70-3
I-Molecular Formula	I-C24H30ClNO3
Isisindo Sefomula	415.95
Ukubukeka	I-crystalline eqinile emhlophe ukuya kokumhlophe
Isivivinyo	98.0% iminithi
I-Melting Point	220-222 °C
Iphuzu elibilayo	527.9 C Ku-760 MmHg
Iphakheji	20kg/bag/drum, 25kg/bag/drum, noma njengoba ubufuna
Isitoreji	Gcina isitsha sivalwe ngokuqinile endaweni eyomile nepholile.Ungachazi elangeni eliqondile.
I-COA ne-MSDS	Iyatholakala
Isicelo	Ngenhloso yocwaningo

Isitifiketi Sokuhlaziya/i-COA:

HLOLA INTO	INKCAZO	RESULT
Ukubukeka	Impushana emhlophe iye komhlophe	Iyahambisana
Ukuncibilika	Incibilika ngokukhululeka ku-chloroform, inyibilika emanzini ne-Acetic acid, inyibilika kancane ku-Acetonitrile ne-ethanol, ayincibiliki ku-Ethylacetoacetate ne-n-hexane.	Iyahambisana
Ukuhlonza	(1) Ngokumuncwa kwe-IR, Ukufanisa nezinga lokusebenza.	Iyahambisana
	(2) Isikhathi sokugcina sesilinganiso esiphakeme kakhulu sesampula kufanele sihambisane naleso sezinga lokusebenza.	Iyahambisana
	(3) Hlola ama-chloride.Iphendula ukuhlolwa kwe-Chlorides.	Iyahambisana
Amanzi	≤0.4%	0.31%
Izinsalela ekushiseni	≤0.1%	0.02%
Into ehlobene	I-Desbenzyl donepezl^a≤0.15% I-analogue ye-Donepezil pyridine^b≤0.15% I-Donepezilzilbenzyl bromide^c≤0.15% I-Dehydrodeoxy donepezil^d≤0.15% I-Deoxy donepezil^e≤0.15% Noma yikuphi ukungcola okukodwa okungaziwa≤0.10% Isamba ≤0.5%	Ayitholakali Ayitholakali 0.02% Ayitholakali Ayitholakali 0.05% 0.18%
Insimbi enzima	≤20ppm	≤20ppm
Izincibilikisi Ezisele	I-Methanol≤0.3%I-Ethanol≤0.5%I-Ethyl acetate≤0.5% I-Toluene≤0.089% I-acetic acid≤0.5%	Ayitholakali Ayitholakali Ayitholakali Ayitholakali Ayitholakali
Isivivinyo	Esisekelweni esomisiwe, uC₂₄H₂₉NO₃·I-HCl kufanele ibe ngu-98.0% ukuya ku-102.0%.	99.52%