Ukuhlola kubonise imvamisa ephezulu yezibulala-magciwane ze-quaternary ammonium njengokwelashwa kwamagciwane amaningi, okuhlanganisa nama-coronavirus: lezi zenza ngokuvala ukuvikela kwe-lipid enamathelayo okumboze amagciwane afana ne-SARS-CoV-2 athembele kuwo.Izinhlanganisela ze-Quaternary ammonium zituswa kabanzi ukubulala amagciwane futhi kunemikhiqizo engaphezu kuka-350 ohlwini lwe-EPA N: Izibulala-magciwane ezizosetshenziswa ngokumelene ne-SARS-CoV-2 (Izinto Ezongeziwe. amakhemikhali asohlwini lwe-EPA abikiwe futhi > angu-140 angalivala igciwane emizuzwini embalwa nje (18).
Lolu lwazi lusiholele ekusesheni okukhudlwana kwezinhlanganisela ze-quaternary ammonium ezinomsebenzi omelene nama-coronavirus kanye nokuhlonza okungenzeka kwamakhemikhali asehloliwe emtholampilo futhi angasetshenziswa njengendlela yokwelapha engaba khona ye-COVID-19.Esinye sezibulali magciwane esikhonjiswe ukuthi sibhubhisa amagciwane (Supplementary Material) futhi sisetshenziswa kakhulu emikhiqizweni yokunakekela abantu i-cetylpyridinium chloride.Lesi sithako sitholakala kakhulu ezindaweni zokuwasha umlomo futhi sifakwe ohlwini yi-FDA Njengebhekwa Ngokujwayelekile Njengephephile (GRAS) kangangokuthi siphinde sisetshenziswe njenge-ejenti elwa namagciwane emikhiqizo yenyama nezinkukhu (kufika ku-1%).I-Cetylpyridinium chloride isetshenziswe ezivivinyweni eziningi zemitholampilo, okuhlanganisa njengokwelashwa ngokumelene nezifo zokuphefumula okuqinisekisa ukusetshenziswa kwayo njenge-antiviral.I-Cetylpyridinium cishe ikhuthaza ukungasebenzi kwegciwane ngokubhubhisa i-capsid kanye nangesenzo sayo se-lysosomotropic, njengoba kuxoxiwe ngenhla, esivamile kuma-quaternary ammonium compounds.Lokhu kuphakamisa umbuzo wokuthi ingabe eminye yemithi ehlotshaniswa nomsebenzi wokulwa namagciwane ngokumelene ne-SARS-CoV-2 in vitro iziphatha ngendlela efanayo, okungukuthi ingabhubhisa i-capsid yegciwane kanye nokunqwabelana ku-lysosome noma endosomes futhi ekugcineni ivimbe ukungena kwegciwane.Ucwaningo olwengeziwe olushicilelwe luphakamise ukuthi lo mphumela ungancishiswa ngokusetshenziswa kwe-Cathepsin-L inhibitors.
I-Cetylpyridinium chloride(CPC)
I-quaternary ammonium compounds nomsebenzi owaziwayo we-coronavirus
| Ingqamuzana | Umsebenzi we-Antiviral | Indlela | I-FDA igunyaziwe | Isebenzisa |
| I-Ammonium chloride | I-Murine coronavirus, i-hepatitis C, | I-Lysosomotropic | Yebo | Ukusetshenziswa okuhlukahlukene kufaka phakathi i-metabolic acidosis. |
| I-Cetylpyridinium chloride | Umkhuhlane, i-hepatitis B, i-poliovirus 1 | Ithagethi ye-capsid futhi iyi-lysosomotropic | Yebo, i-GRAS | I-Antiseptic, i-mouthwash, i-lozenge yokukhwehlela, imikhiqizo yokunakekelwa komuntu siqu, izinto zokuhlanza njll. |
Isikhathi sokuthumela: Aug-03-2021